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Monday, November 23, 2020 | History

1 edition of Theophylline in airways obstruction found in the catalog.

Theophylline in airways obstruction

Theophylline in airways obstruction

proceedings of a panel discussion held at the Royal Society of Medicine, London, on 17 August 1981

by

  • 350 Want to read
  • 17 Currently reading

Published by The Society in London .
Written in English

    Subjects:
  • Airway Obstruction -- drug therapy -- congresses,
  • Lung Diseases, Obstructive -- drug therapy -- congresses,
  • Lungs -- Diseases, Obstructive -- Chemotherapy -- Congresses.,
  • Respiratory organs -- Obstructions -- Chemotherapy -- Congresses.,
  • Theophylline -- Physiological effect -- Congresses.,
  • Theophylline -- pharmacodynamics -- congresses,
  • Theophylline -- therapeutic use -- congresses

  • Edition Notes

    Includes bibliographical references.

    Statementedited by Clive Wood and Yvonne Rue.
    SeriesForum series (Royal Society of Medicine (Great Britain)) -- no.3, Forum series (Royal Society of Medicine (Great Britain)) -- no. 3
    ContributionsRue, Yvonne., Wood, Clive., Royal Society of Medicine (Great Britain)
    Classifications
    LC ClassificationsRM66T39 T54 1981
    The Physical Object
    Pagination17 p. --
    Number of Pages17
    ID Numbers
    Open LibraryOL19210299M

    Using a double-blind, placebo-control, crossover study design, 8 asthmatic children ( years) were evaluated for temporal patterns in airways function throughout separate study periods when


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Theophylline in airways obstruction Download PDF EPUB FB2

Theophylline readily binds to absorbents and food may act similarly to decrease the amount available for absorption.

Slow Release Theophylline in Airways Obstruction The effect of food in reducing the serum levels of theophylline is unlikely to cause any clinical problems if Slow release theophylline in patients with airways obstruction with particular reference to the effects of food upon serum levels.

Thompson PJ, Theophylline in airways obstruction book MW, McAllister WA, Turner-Warwick M. Eighteen patients with airways obstruction were given slow release theophylline and were then investigated to determine the influence of a standard meal upon Sustained release theophylline in the treatment of chronic reversible airways obstruction: international workshop, Mont Ste Marie, Canada   The optimal serum concentration of theophylline for the management of acute airways obstruction was evaluated by comparing the response to target concentrations at the extremes of the usual therapeutic range.

patients requiring intravenous theophylline were randomly assigned to a target concentration of 10 or 20 mg/L. Control of theophylline dosage using measured theophylline Clinical Applications.

Theophylline is used in the treatment of patients with reversible airways obstruction (asthma and chronic obstructive lung disease). Modes of Administration. Theophylline is normally administered orally as a modi-fied-release preparation. Theophylline can also be given in the form of an ethylenediamine salt (aminophylline) orally or rarely intravenously (must be given   OBJECTIVE--To evaluate measurement of the trapped gas volume as a measure of respiratory function in patients with chronic obstructive airways disease and their response to treatment with theophylline.

DESIGN--Patients able to produce consistent results on testing of respiratory Theophylline in airways obstruction book spent two weeks having dosage of theophylline adjusted to give individual pharmacokinetic ://   Peak expiratory flow rate, adverse effects and serum theophylline concentration were measured during treatment of episodes of severe airways obstruction.

patients were randomised to target theophylline concentrations of 10 mg/L or 20 mg/L. The recovery of peak flow rate towards normal values was explicable in terms of time and theophylline concentration using semiparametric and Theophylline is used in the treatment of bronchospasm - ie in reversible airways obstruction and severe asthma.

It is a bronchodilator available in modified release preparations which are able to provide therapeutic plasma concentrations for 12 ://?ID= Theophylline has two distinct actions on the airways of women with reversible airway obstruction: bronchodilation and nonbronchodilator prophylactic effects.

Although 1% of pregnant women have asthma, it is often underrecognized and suboptimally :// /theophylline. Recurrent airway obstruction (RAO) is an inflammatory, obstructive airway disease that becomes clinically evident in middle-aged horses.

Attacks of airway obstruction are induced by exposure of susceptible animals to organic dust (typically hay dust). Following dust exposure, there is a massive influx of neutrophils into the :// Treatment of reversible chronic airways obstruction with doxofylline compared with slow-release theophylline: a double-blind, randomized, multicentre trial.

Melillo G(1), Balzano G, Jodice F, De Felice A, Campisi V, Capone M, Di Filippo A, Foddai G, Franzone JS, Grossi E, et al. Author information: (1)Cardarelli Hospital, Naples, :// Theophylline has two distinct actions in the airways of patients with reversible obstruction; smooth.

muscle relaxation (i.e., bronchodilation) and suppression of the response of the airways to stimuli (i.e.,?setid=fda1ade2-ac. The natural history of chronic obstructive pulmonary disease (COPD) is characterised by an accelerated annual decline in forced expiratory volume in one second (FEV1).

One of the most crucial factors in COPD is therefore the means by which this annual decline can be delayed.

Bronchodilator therapy is usually prescribed to relieve the symptoms, reverse airway obstruction and, hopefully, to Eighteen patients with airways obstruction were given slow release theophylline and were then investigated to determine the influence of a standard meal upon the serum levels achieved over the ensuing hour period.

After food the peak to trough differences were decreased and the serum levels were significantly lower over the first 6 :// Airway inflammation is a common feature of bronchial asthma, chronic bronchitis and chronic obstructive lung diseases.

The aim of this article is to review the evidence that airway inflammation plays a substantial role in the pathogenesis and long-term evolution of these diseases and to demonstrate that theophylline influences airway inflammation at therapeutic ://   benefit from theophylline in relieving pulmonary symptoms caused by irreversible airwayobstruction.

Therefore, to avoidconfusion, "asthma" in this article refers to reversible airways obstruction and COPD to chronic irreversible airways obstruction. *From the Division ofClinical Pharmacokinetics, College of Phar­(16)/pdf. Summary In a double blind cross‐over comparison of a single dose ‐mg slow‐release aminophylline (SRA) with placebo in eleven patients with stable, reversible airways obstruction SRA produced significantly greater increase in FEV1 and vital capacity from 2 to 9 hr after administration.

A second double‐blind cross‐over comparison of ‐mg SRA with mg of choline theophyllinate Theophylline is used in the treatment of patients with reversible airways obstruction (asthma and chronic obstructive lung disease).

Modes of Administration. Theophylline is normally administered orally as a modi-fied-release preparation. Theophylline can also be given in the form of an ethylenediamine salt (aminophylline) orally or rarely 1 The effect of a controlled release theophylline derivative (Phyllocontin Continus tablets) and an adrenoceptor agonist (salbutamol) was compared when taken singly and concomitantly in twenty patients with chronic bronchitis and additional reversible airways obstruction using a double-blind crossover technique.

2 The pulmonary function data   Theophylline was primarily used as a bronchodilator, and it relaxes large and small human airways in vitro, acting as a functional antagonist by increasing intracellular cAMP concentrations.

However, it is a relatively weak bronchodilator at therapeutic concentrations, with little bronchodilator effect at plasma concentrations of less than 10 mg/:// Theophylline: a diagnostic aid for evaluating chronic airways obstruction.

dal Negro RW, Pomari C, Zoccatelli G, Turco P, Serra E. A study was carried out on the use of theophylline ( mg by infusion) as a functional diagnostic test in patients showing severe chronic airways :// The older group had lower baseline pulmonary function values, suggestive of a greater degree of baseline airways obstruction.

Despite wide intersubject variability, the elderly subjects demonstrated a lower absolute change in bronchodilator response to equal concentrations of theophylline than did their younger counterparts (P A data set is provided which was collected as part of a target concentration controlled trial of theophylline in severe airways obstruction (Holford et al.

a) Measurements of peak expiratory flow rates (PEFR) and theophylline concentration were made in patients assigned to a target concentration of 10 mg/L or 20 mg/L. Available Theophylline has emerged as a major prophylactic agent for controlling the symptoms of chronic asthma, but it provides little if any relief of pulmonary symptoms caused by irreversible chronic airways obstruction.

Although in vitro it inhibits phosphodiesterase and antagonizes adenosine receptors, theophylline's mechanism of action in asthma is ://(16)/fulltext. 1 The effect of a controlled release theophylline derivative (Phyllocontin Continus tablets) and an adrenoceptor agonist (salbutamol) was compared when taken singly and concomitantly in twenty pati Introduction.

Airways inflammation is thought to play a central role in the pathogenesis of asthma. Clinical investigations show a correlation between the presence of activated inflammatory cells (neutrophils, mast cells, and eosinophils), histological changes to pulmonary tissue, and the development of airways hyperreactivity (Wagelie steffen et al., ).

“Theophylline relaxes the smooth muscles in your airways so they open up and can let air flow through them more easily,” says Asthma UK’s in-house GP Dr Andy Whittamore.

When you take theophylline at home it’s usually as a tablet or capsule that lasts all :// /inhalers-medicines-treatments/add-on-treatments/theophylline.

Theophylline is a natural alkaloid derivative of xanthine isolated from the plants Camellia sinensis and Coffea arabica. Theophylline appears to inhibit phosphodiesterase and prostaglandin production, regulate calcium flux and intracellular calcium distribution, and antagonize logically, this agent relaxes bronchial smooth muscle, produces vasodilation (except in cerebral In a double-blind, placebo-controlled study, three groups of adult asthmatic patients with reversible airways obstruction received microcrystalline theophylline in a dosage of mg, mg or obstruction was carefully excluded, theophylline de- creased dyspnea to a small and significant degree but did not alter exercise performance.5 Thus, effects of /   Optimizing the management of children presenting with acute severe asthma is of utmost importance to minimize hospital stays, morbidity, and mortality.

Intravenous medications, including theophyllines, are used as second-line treatments for children experiencing a life-threatening exacerbation. For intravenous theophylline (aminophylline), guidelines and formularies recommend a   Time and theophylline concentration help explain the recovery of peak flow following acute airways obstruction.

Population analysis of a randomised concentration-controlled trial. Clinical Pharmacokinetics b; Holford NHG, Peace Mechanism of Action: Theophylline has two distinct actions in the airways of patients with reversible obstruction; smooth muscle relaxation (i.e., bronchodilation) and suppression of the response of the airways to stimuli (i.e., non-bronchodilator prophylactic effects).

While the mechanisms of action of theophylline are not known with certainty, studies in animals suggest that ?setid=9edbcfe-8c4a.

Theophylline has two distinct actions in the airways of patients with reversible obstruction; smooth muscle relaxation (i.e., bronchodilation) and suppression of the response of the airways to stimuli (i.e., non-bronchodilator prophylactic effects).

While the mechanisms of action of theophylline are not?setid=31f3cdb. Theophylline (3-methyxanthine) has been used to treat airway diseases for over 70 years. It was originally used as a bronchodilator but the relatively high doses required are associated with frequent side effects, so its use declined as inhaled β2-agonists became more widely used.

More recently it has been shown to have anti-inflammatory effects in asthma and COPD at lower :// Theophylline alone does not appear to have much place in the management of patients with partially reversible obstructive airways disease. Full text Get a printable copy (PDF file) of the complete article (K), or click on a page image below to browse page by The diagnosis of reversible airways obstruction (RAO) is sometimes difficult.

It is usually established when an inhaled bronchodilator results in a documented improvement of 15 percent or greater in the forced expiratory volume in 1 s (FEV 1 or the forced vital capacity (FVC), or in a 20 percent or greater increase in the mean expiratory flow rate between 25 percent and 75 percent of the (16)/fulltext.

Theophylline has two distinct actions in the airways of patients with reversible obstruction; smooth muscle relaxation (i.e., bronchodilation) and suppression of the response of the airways to stimuli (i.e., nonbronchodilator prophylactic effects).

While the mechanisms of action of theophylline are not known?setid=9aeffbdb. It is also used as an adjunct in the treatment of congestive heart failure and acute pulmonary edema, but it has no established efficacy in patients with chronic irreversible airways obstruction.

Benefits and risks from theophylline relate directly to serum concentration, which is a function of both dose and elimination characteristics of the @ The influence of orally administered cimetidine and theophylline on the elimination of each drug in patients with chronic airways obstruction.

Am Rev Respir Dis. ; (5) (ISSN: ). Chronic obstructive pulmonary disease (COPD), caused by chronic inflammation and destruction of the airways and lung parenchyma is usually associated with tobacco smoking or prolonged exposure to other noxious particles and gases. It is a major health problem characterized by progressive airflow obstruction that is sometimes partially reversible.

Methylxanthines like theophylline have been Theophylline appears to diffuse better in bronchial tissue than other methylxanthines (van Zyl et al. ), and this should justify its preferential use over the ://Theophylline is a well known bronchodilator which has been used for more than 50 years in the treatment of obstructive pulmonary diseases.

In patients with severe chronic obstructive pulmonary